Read next. September 04, Receive an email when new articles are posted on. Please provide your email address to receive an email when new articles are posted on. You've successfully added to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts. The American Heart Association AHA recommends extended-release amoxicillin as an alternative to penicillin V for rheumatic fever prophylaxis.
Children younger than 2 years should be treated with amoxicillin; clavulanic acid, not amoxicillin alone. Treat all patients younger than 2 years and patients 2 years and older with severe disease for 10 days. For children 2 to 5 years with mild to moderate disease, a 7-day course is acceptable.
For children 6 years and older with mild to moderate disease, a 5- to 7-day course is acceptable. Young infants are less capable of responding to infection, and the clinical manifestations of infection can be subtle.
Because of the increased risk for complications of an undiagnosed systemic infection, every young infant presenting with a fever should be carefully evaluated. Guide treatment duration by clinical stability. For less resistant pneumococcal strains MIC of 0. A double-blind, randomized trial compared amoxicillin without probenecid with azithromycin in patients with erythema migrans. Those treated with amoxicillin were significantly more likely than those treated with azithromycin to achieve complete resolution by day 20, the end of the study.
Significantly more azithromycin recipients relapsed than amoxicillin recipients. The dose of amoxicillin in this study was mg PO 3 times per day for 20 days. Maximum 1. Amoxicillin — mg PO three times daily with metronidazole mg PO three times daily for 7—10 days. Prophylaxis is recommended for at-risk cardiac patients undergoing dental procedures that involve manipulation of gingival tissue, manipulation of the periapical region of teeth, or perforation of the oral mucosa.
Cardiac patients that are considered to be at highest risk include those with prosthetic cardiac valves or prosthetic material used for cardiac valve repair, previous infective endocarditis, select types of congenital heart disease CHD , and cardiac transplantation with valvulopathy.
Clarithromycin-containing regimens are associated with a high eradication rate and less side effects than regimens that include metronidazole. For patients with an active ulcer, an additional 14 days of omeprazole 20 mg once daily is recommended for ulcer healing. More effective triple drug regimens are available and recommended. The original FDA-approved dual regimen consists of amoxicillin 1, mg PO and lansoprazole 30 mg PO , each given three times daily for 14 days. The dual regimens consisted of levofloxacin mg PO once daily with rabeprazole 20 mg PO once daily for 5, 7, or 10 days.
The triple regimen included amoxicillin 1, mg PO twice daily, levofloxacin mg once daily , and rabeprazole 20 mg once daily for 7 days. Treat for 7 to 10 days for naturally acquired infection. For a bioterrorism-related event, treat for a total duration of 60 days.
Following initial treatment for severe anthrax infection, amoxicillin as a single agent may also be used as follow-up treatment. For a bioterrorism-related event, continue treatment for 60 days. As oral follow-up combination therapy after initial IV therapy for severe anthrax non-CNS infection , use amoxicillin in combination with a protein synthesis inhibitor i.
Continue therapy to complete a treatment course of at least 14 days; additional prophylaxis to complete an antimicrobial course of up to 60 days may be required. Administration of broad-spectrum antibiotics has been shown to prolong pregnancy, reduce maternal and neonatal infections, and reduce gestational age-dependent morbidity. No dosage adjustment needed; amoxicillin is not appreciably metabolized in the liver and does not undergo biliary secretion. The following dosing recommendations pertain to adults.
No specific dosage adjustments for pediatric patients with renal impairment are available at this time; however, dosage intervals should be adjusted. Do not use the mg-tablet strength or the extended-release tablet for dosing. Intermittent hemodialysis For adults, — mg PO every 24 hours, depending on the severity of the infection.
According to the manufacturer, an additional dose should be given both during and at the end of a dialysis session. Moxatag extended-release tablets mg : Take within 1 hour of finishing a meal. Do not chew or crush. Chewable tablets: Should be chewed before swallowing; do not swallow whole. In general, amoxicillin capsules and chewable tablets may be given without regard to meals. The mg chewable tablet and the mg tablet have been studied only when administered at the start of a light meal.
In general, amoxicillin oral suspension may be given without regard to meals. The mg suspension has been studied only when administered at the start of a light meal. Shake well prior to each administration. Measure dosage with calibrated spoon, cup, or oral syringe. The measured dose of suspension may be added to formula, milk, fruit juice, water, ginger ale, or cold drinks for administration.
These preparations should be administered immediately and consumed in their entirety to ensure all of the dose is received. Reconstitution method for oral suspension: Review the reconstitution instructions for the particular product and package size, as the amount of water required for reconstitution varies from manufacturer to manufacturer. Prior to reconstitution, tap the bottle several times to loosen the powder.
Add the remainder of the water and shake well. Storage after reconstitution: Store under refrigeration preferred or at controlled room temperature for up to 14 days. Discard any unused portion after 14 days. Generic: - Store at controlled room temperature between 68 and 77 degrees F Amoxil: - Store at controlled room temperature between 68 and 77 degrees F Moxatag: - Store at 77 degrees F; excursions permitted to degrees F Moxilin : - Store at controlled room temperature between 68 and 77 degrees F Sumox: - Store at controlled room temperature between 68 and 77 degrees F Trimox: - Store at controlled room temperature between 68 and 77 degrees F.
Amoxicillin is a penicillin and is contraindicated in patients with a penicillin hypersensitivity. In general, amoxicillin should be used cautiously in patients with cephalosporin hypersensitivity or carbapenem hypersensitivity.
Amoxicillin is contraindicated in patients with a known serious hypersensitivity reaction i. Patients with allergies or atopic conditions including asthma, eczema, hives urticaria , or hay fever may have a greater risk for hypersensitivity reactions to penicillins. Use amoxicillin with caution in patients with renal impairment as the drug is substantially eliminated via renal mechanisms. Dosage adjustments are also recommended for patients receiving dialysis.
Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from mild to life-threatening. In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to antibacterial administration.
The toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis. It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis. Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting with diarrhea following antibacterial administration. Systemic antibiotics should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease.
If diarrhea develops during therapy, the drug should be discontinued. Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted. In milder cases, the colitis may respond to discontinuation of the offending agent. In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted. Products inhibiting peristalsis are contraindicated in this clinical situation.
Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should be taken. Based on manufacturer data, geriatric patients above 65 years do not respond differently to amoxicillin treatment than younger patients.
However, a greater sensitivity to amoxicillin in elderly patients could not be ruled out. Amoxicillin is known to be substantially excreted via the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection for elderly patients; renal function monitoring may be useful.
According to OBRA, use of antibiotics should be limited to confirmed or suspected bacterial infections. Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such as oral thrush, colitis, or vaginitis.
Any antibiotic may cause diarrhea, nausea, vomiting, anorexia, and hypersensitivity reactions. Amoxicillin is classified in FDA pregnancy risk category B. Animal data reveal no teratogenic effects, however, there are no adequate and well-controlled studies in pregnant women. While amoxicillin should be used with caution in pregnancy, penicillins are usually considered safe during pregnancy when clearly needed. According to the manufacturer, amoxicillin should be used cautiously during breast-feeding due to the potential for sensitization of the infant.
Unless the infant is allergic to penicillins, breast-feeding is generally safe during maternal penicillin therapy. The American Academy of Pediatrics considers amoxicillin a medication that is usually compatible with breast-feeding. Amoxicillin is excreted in breast milk in small amounts.
Penicillins may cause diarrhea due to disruption of GI flora , candidiasis, and skin rash in breast-feeding infants. Small studies assessing adverse events in breast fed infants exposed to antibiotics have found adverse event rates of 7. The adverse events reported included diarrhea, rash, and somnolence. The infant should be observed for potential effects. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition.
If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. Patients with phenylketonuria should be warned that the chewable tablets and the tablets for oral suspension DisperMox contain phenylalanine. Amoxicillin chewable tablets contain phenylalanine in the amount of 1.
Each mg and mg DisperMox Tablet for oral suspension contains 5. The oral suspensions do not contain phenylalanine. According to the manufacturer, amoxicillin should not be used in patients with mononucleosis as a high incidence of skin rashes have been reported in these patients.
While amoxicillin may be used to treat certain sexually transmitted diseases STD , the drug may mask or delay the symptoms of incubating syphilis when given as part of an STD treatment regimen. Initiate appropriate therapy and perform follow-up testing as recommended based upon sexually transmitted disease diagnosis. Administration of amoxicillin may result in laboratory test interference. A false-positive reaction for glucose in the urine has been observed in patients receiving penicillins and using Benedict's solution, Fehling's solution, or Clinitest tablets for urine glucose testing.
Patients with diabetes mellitus who test their urine for glucose should use glucose tests based on enzymatic glucose oxidase reactions while on amoxicillin treatment.
Antimicrobials are also known to suppress H. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.
For women who are breastfeeding: Amoxicillin may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.
This dosage information is for amoxicillin oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:. Children who weigh more than 88 pounds should be dosed according to the adult recommendations.
It has not been confirmed that amoxicillin extended-release tablets are safe and effective for use in people younger than 12 years of age. The kidneys of older adults may not work as well as they used to. Your doctor may start you on a lower dose or a different dosing schedule.
This can help keep levels of this drug from building up too much in your body. The dosage listed here is meant for children who weigh less than 88 pounds 40 kg.
This is meant for children who weigh less than 88 pounds 40 kg. This medication should not be used in children younger than 2 years of age for treatment of gonorrhea. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you. Amoxicillin oral tablet is used for short-term treatment.
For this drug to work well, a certain amount needs to be in your body at all times. Do not stop taking the drug or skip doses if you start to feel better. This could cause your infection to last longer. You could also develop a resistance to the medication.
This means if you get a bacterial infection in the future, you may not be able to treat it with amoxicillin. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:. If your symptoms are severe, call or go to the nearest emergency room right away. What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once.
This could result in dangerous side effects. Keep this drug away from light. A prescription for this medication may be refillable.
You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. You and your doctor should monitor certain health issues.
This can help make sure you stay safe while you take this drug. These issues include your:. There are other drugs available to treat your condition.
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